摘要：Trichomoniasis, a worldwide prevalent infection, is a perfect example of
interplay between the infecting parasite and the host, on which the presentation
of disease depends. To study the pathogenesis, animal model is required for
establishment of infection. In this study, by using strains of Trichomonas
vaginalis isolated from vaginal swabs and/or urine samples and maintained in
axenic form from 10 symptomatic and 10 asymptomatic female patients, the
infections in BALB/c mice have been evaluated. Based on parasitic load,
experimental peak infection in vagina of estradiol and L. acidophilus treated
female BALB/c mice was observable on 5th post infection day. This was
significantly higher in mice infected with isolates from symptomatic patients in
comparison to the other group. Gradual increase up to day 5 followed by decline
in parasites, polymorphs and vaginal epithelial cells was observed in mice
infected with isolates from symptomatic subjects in contrast to mice infected
with asymptomatic patients’ isolates or control animals at all time intervals.
关键词：Trichomoniasis vaginalis ، Animal model ، Lactobacilli
