To address the health and financial burden of chronic disease in communities and advance public health practice in the 21st century, the Centers for Disease Control and Prevention’s Steps Program, established in 2003, funds selected national organizations and communities nationwide to implement evidence- and practice-based community interventions. These interventions focus on reducing obesity, diabetes, and asthma and addressing the underlying risk factors of physical inactivity, poor nutrition, and tobacco use. Building on successes and lessons learned from the Steps Program, CDC has broadened its investment in communities through the creation of CDC’s Healthy Communities Program, of which Steps is now a part. The Healthy Communities Program mobilizes communities across the nation to take local action to prevent and reduce the impact of chronic disease. Many key policy, systems, and environmental decisions that affect chronic disease rest in the hands of local decision makers.