摘要：This review highlights the role of oxidative stress and imbalances in metal ion homeostasis
in the neurodegenerative diseases Alzheimer’s disease and Parkinson’s disease and in the progressive
demyelinating disease multiple sclerosis. The chemistry and biochemistry of oxidative stress-induced protein
damage are first described, followed by the evidence for a pathological role of oxidative stress in these disease
states. It is tempting to speculate that free radical oxygen chemistry contributes to pathogenesis in all these
conditions, though it is as yet undetermined what types of oxidative changes occur early in the disease, and
what types are secondary manifestations of neuronal degeneration.
