摘要：There is a growing interest to evaluate metals in biological fluids in Alzheimer’s disease
(AD). There are numerous studies on this theme, but just few papers analyzed the relationship between
haematic metal concentrations and the clinical features of the disease. In this study, possible associations
between clinical features of AD and the variations in serum and blood concentration of some metals, as well
as the serum oxidative status and the antioxidant capacity have been investigated. Sixty subjects with AD were
enrolled. Some elements correlated with gender, depression and duration of the disease. However, the most
significant result was the relationship between blood Ca and Fe levels and the severity of cognitive impairment.
We hypothesize that Ca and Fe might play an important role in the pathogenetic mechanisms of AD.
