标题：Concentration of elements in serum of patients affected by multiple sclerosis with first demyelinating episode: a six-month longitudinal follow-up study
摘要：Twenty-six chemical elements and oxidative status were determined in serum of 12 patients
with first demyelinating episode and brain magnetic resonance imaging compatible with the disease at
different time points. Quantifications of Al, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Ni, Pb,
Sb, Si, Sn, Sr, V, Tl, W, Zn and Zr, as well as of serum oxidative status and antioxidant capacity were carried
out. The results were compared with values obtained from healthy subjects living in the same geographic area.
Concentration variability, expressed as coefficient of variation (CV), was evaluated over a six months
longitudinal follow-up. The CV was higher for Li and Pb, while showed minimal variation for Ca, Cu, Mg and
Zn - elements strictly body regulated. Significant difference (p ≤ 0.05) in mean concentrations of Ba, Ca, Cd,
Cr, Li, Mn, Mo, Ni, Sb, Si, Sn and Zr between patients at time 0 and controls was also found.
关键词：multiple sclerosis, chemical elements, serum, oxidative stress, first demyelinating episode.
