期刊名称：Facta Universitatis : Series Physical Education and Sport
印刷版ISSN：1451-740X
出版年度：2005
卷号：3
期号：01
页码：11-22
出版社：University of Niš
摘要：The effects of an injection (ip) of ethionine (1.0 mg/g) with and without methionine (1.0 mg/g) were studied at rest and following a 30-min bout of exercise (26 m/min, 0% grade) in female Sprague-Dawley rats. Ethionine, compared to a NaCl injection, resulted in a significant (P < 0.05) decrease in resting levels of liver ATP, liver glycogen, and plasma glucose and in a significant increase in liver Pi/ATP ratio and plasma FFA, glycerol, glucagon, and norepinephrine concentrations. All of these responses were restored by the addition of methionine. None of these responses were amplified by the combination of ethionine and exercise stimuli. These results indicate a predominance of ethionine over the exercise stimulus and suggest that intra hepatic events related to a decreased ATP level in the liver exert a powerful regulatory influence on the metabolism.
