期刊名称：Fibre Diffraction Review : the CCP13 Newsletter ; Software Development for Fibre Diffraction (Formerly The CCP13 Newsletter)
印刷版ISSN：1463-8401
电子版ISSN：1463-8401
出版年度：2003
卷号：11
出版社：CCLRC Daresbury Laboratory
摘要：Rat-tail tendon is primarily composed of type I
collagen fibres in which the collagen molecules are
axially packed according to the quarter-stagger
model (Hodge and Petruska (1963). This
arrangement produces the characteristic meridional
series of reflections in the X-ray diffraction pattern
of this tissue. Crystalline-like lateral packing
interactions produce a series of discrete but often
overlapping Bragg reflections arranged as rowlines
in the equatorial plane of the X-ray diffraction
pattern. Analysis of the equatorial reflections reveals
that the collagen molecules are packed on a nonstandard
quasi-hexagonal lattice, where the unit cell
is triclinic (Fraser et al.,1983; 1987; Wess et al.,
1995; 1998; Orgel et al., 2001). The equatorial rowlines
are overlaid by a continuous layer of diffuse
scatter, thought to arise from liquid-like molecular
disorder, particularly in the gap region (Hulmes et
al., 1995). Some of the diffuse scatter is removed on
cryo-cooling the sample to 90-100 Kelvin during
data collection and some non-physically by
mathematical means (Wess et al., 1998). Analysis of
the component underlying Bragg peaks and of the
distribution and intensity of the diffuse scatter at
different temperatures will help to further clarify the
positions, mobilities and paths of the molecular
segments within the gap and overlap regions of the
triclinic unit cell.
