摘要：Inflammatory bowel disease with it’s two distinct entities, ulcerative colitis (UC) and Crohn’s disease (CD) with increased morbidity, uncertain etiopathogenesis, severe complication, early invalidity represents a major problem of public health in many regions of the world. The aim of the our study was to present some medical, social and economic aspects of IBD relevant for public health and which resulted from comparative evaluation of this epidemiological phenomena and its evolution in NE Romanian region as well as in other regions in the world. Material and method. The size of the studied population samples (10.81% of the total population of Romania ) allowed us to record 942 cases of IBD in NE Romania region during two decades. The necessary data in order to evaluate the frequency and clinical course has been drawn from medical records as well as statistic reports presented by the literature in the field. Results. The IBD incidence in NE Romania was 1.89/105 inhabitants (1.54/105 inhabitants for UC and 0.35/105 inhabitants for CD). In 65% of the cases, the onset of the disease was found at persons younger than 50 years. By evaluating the environmental factors in the appearance of IBD it has been proved that it is present more frequently at nonsmoker and without appendectomy patients, while CD is more frequently in smoking patients. The family history frequency within IBD patients was about 2.4% and pANCA was identified in 11% patients with UC. Active disease with sever attacks was reported in 21% patients at IBD onset and in 41% of the patients with severe complications (such as toxic megacolon reported in 2.2%). Dysplasia, as main pre malignant lesion was identified in 4.4% patients who presented colon mucosal changes. Conclusion. IBD incidence of 1.89/105 places the NE Romania zone in the geographical region groups with low frequency in conformity with European statistic data. Nevertheless high frequency in young in youth people, the high risk cancer and severe evolution of the disease, high costs include this complex disease within important public health problems, that should must be included in National Health Program.
关键词：inflammatory bowel disease, public health, frequency, clinical pattern
