摘要：For 50 years , it was generally believed that the major caries – preventive effect of fluoride was pre-eruptive. But there is a general agreement today among scientists in the field of fluoride research that the caries-preventive and the caries controlling effects of fluorides are almost exclusively post-eruptive ,as topical fluoridation , because fluoride reduces the demineralisation effects of organic acids produced by the cariogenic bacteria in the dental plaque and accelerates remineralisation after the attack .
