标题：Evaluation of lipid parameters, homocysteine, adhesion molecules and carotid intima-media thickness in children from families with circulatory system diseases history
摘要：The evaluation of lipid parameters, homocysteine, soluble adhesion molecules in the blood serum and the thickness of common carotid artery wall in children from families with diagnosed risk factors of atherosclerosis. Material and methods: The study included 18 children (8 girls and 10 boys) aged 2-3 years and their parents from families with circulatory system disease in their history. The control group was composed of 16 children (8 girls and 8 boys) aged 2-3 years from families without that risk. In all of the subjects concentrations of triglycerides, total cholesterol and its fractions: LDL, VLDL, HDL and of apolipoproteins (apo-AI, apo-B), lipoprotein (a), homocysteine as well as of sICAM-1 (intracellular adhesion molecule-1), sVCAM-1 (vascular cell adhesion molecule-1) and sE-selectin in the blood serum were determined. The intima-media thickness (IMT) measurement was made with ultrasonographic method in children and their parents from families with positive history and in children from families with negative history. Results: The concentration of triglycerides, VLDL cholesterol and lipoprotein (a) had the highest value in the blood serum of the children from the families with risk factors of atherosclerosis as compared to the levels of the children from families without that risk and the differences were statistically significant (p<0.05). The evaluation of the relationship between the IMT and lipids, lipoproteins, apolipoproteins, homocysteine and soluble adhesion molecules in children from families with risk of cardiac ischaemia and in children from control group did not confirm any significant statistically correlations. The statistically significant positive correlation was confirmed between IMT and total cholesterol in mothers and between IMT and apo-B in fathers from families with positive history. Conclusion: The significant increase in the concentrations of triglycerides, VLDL and lipoprotein (a) in children with positive family history of atherosclerosis risk indicates that this group is particularly exposed to early atherosclerotic changes. We are planning to continue the research in this group of children in order to find the atherosclerosis risk factors.
