摘要:In order to point out some health effects associated with methemoglobinemia in children , we investigated a battery of oxidative and antioxidant defence bioindicators ( methemoglobin , reduced glutathione , lipid peroxides and glutathione peroxidase ) in 336 children aged 0-3 years living in eight rural localities within three districts , confirmed as high risk territories for nitrate exposure in drinking water . The results showed significant increased lipid peroxides levels in the children exposed to nitrates vs. unexposed group , as a possible early reversible effect of exposure . The investigation also highlighted significant differences of the biochemical changes pattern in 0-3 year aged children at two levels (moderate and high ) of nitrate concentrations in drinking water .