摘要：Streptococcus pneumoniae - major cause of infection in children - causes serious therapeutic difficulties , because of the developed multiresistance . Extended-spectrum cephalosporins , used in empirical therapy are a therapeutic option . Recent emergence of Ceftriaxone (CRO) and Cefotaxime (CTX) resistant strains with regional differences in frequency requires their detection by quantitative determinations . The results of the first study on children from Iasi concerning CRO resistance of S. pneumoniae , evaluated according to NCCLS 2002 criteria , showed the presence of this phenotype in ear and lower respiratory tract infections . Authors recommend quantitative testing for CRO of high level P resistant strains , isolated from these infections , when CRO is a therapeutic option and surveillance of occurrence of this resistance phenotype in strains isolated from non respiratory infections .
