期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2000
卷号：7
期号：02
页码：71-71–78
出版社：Institute of Agricultural Medicine in Lublin
摘要：The objective of the study was to examine the effect of farming exposure,
respiratory symptoms and smoking on the shape of the MEFV-curve in 1,691 male farming
students and 407 male controls and to relate the slope ratio with FEV1 and FEV1/FVC. Each
subject underwent a medical interview and the slope ratios from the MEFV-curve at 75
(SR75), 50 (SR50) and 25 (SR25) %FVC together with FEV1 and FVC were recorded.
Histamine bronchial reactivity (Yan method) was measured and skin prick test with
inhalant allergens was performed. In smokers, SR75 increased with increasing exposure to:
general farming, swine and dairy cattle (p . 0.020). SR50 increased with increasing
exposure to farming (p = 0.015). In non-smokers, SR25 increased with increasing exposure
to swine and dairy cattle (p = 0.021) and increased SR25 was associated with sensitisation
to house dust mite (p = 0.017). Data revealed an interaction between smoking and exposure
to farming. FEV1 and FEV1/FVC was not associated with farming exposure or production
animals. FEV1 and FEV1/FVC (p . 0.003) were lower among subjects with bronchial
hyperresponsiveness and asthma (FEV1 and asthma only in smokers). SR75 (p = 0.037) and
SR50 (p = 0.024) were increased in subjects with asthma and SR75 was increased in
subjects with bronchial hyperresponsiveness, but only in smokers (p = 0.002). In conclusion,
exposure to farming seems to influence the shape of the MEFV-curve and there are
indications of interaction between exposure to organic dust and smoking. These changes are
seen only in the slope ratios and not in FEV1 and FEV1/FVC. However, FEV1 and
FEV1/FVC are superior to slope ratios in differentiating healthy subjects from those with
respiratory symptoms.
