The pattern of the European Union, including Romania as a member state, determines the reconfiguration of Romanian way of acting in order to develop new business. Learning from others with much more experience in the field of regional economic development may be the key to accomplish the goal of economic and social cohesion. The gap between Romania and EU-27 average in economic development terms may be reduced only by promoting small businesses to enhance. Creating jobs and building wealth is the only solution available to the current problems of Romanian economy. The paper intends to respond to basic questions of creating a business incubator. Also, it may be a tool to local and regional promoters that want to give rise, in a proper manner, to a Business Incubator.