摘要：Age-related macular degeneration (ARMD) is a severe disease affecting visual function
in the elderly. Currently available surgical and medical options do not guarantee a significant impact
on the outcome of the disease. We describe the effects of nerve growth factor eye drop treatment in a
94 years old female with ARMD, whose visual acuity was progressively worsening in spite of previous
surgical and medical treatments. NGF eye drops improved visual acuity and electrofunctional
parameters as early as 3 months after initiation of treatment. These results are in line with previous
reports on a neuroprotective effect of NGF on retinal cells and on NGF eye drops bioavailability
in the retina and optic nerve. No side effects were observed after five years of follow-up, suggesting
that topical NGF treatment may be a safe and effective therapy for ARMD.
