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  • 标题:Validation of Anti-aging Drugs by Treating Age-related Diseases
  • 本地全文:下载
  • 作者:Mikhail V. Blagosklonny
  • 期刊名称:Aging
  • 出版年度:2009
  • 卷号:01
  • 期号:03
  • 出版社:U.S.Department of Health & Human Service
  • 摘要:Humans die from age-related diseases, which are deadly manifestations of the aging process. In order to extend life span, an anti-aging drug must delay age-related diseases. All together age-related diseases are the best biomarker of aging. Once a drug is used for treatment of any one chronic disease, its effect against other diseases (atherosclerosis, cancer, prostate enlargement, osteoporosis, insulin resistance, Alzheimer's and Parkinson's diseases, age-related macular degeneration) may be evaluated in the same group of patients. If the group is large, then the anti-aging effect could be validated in a couple of years. Startlingly, retrospective analysis of clinical and preclinical data reveals four potential anti-aging modalities.
  • 关键词:Anti-aging drugs; diseases; cancer; atherosclerosis; resveratrol; rapamycin; metformin
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