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  • 标题:Aging of the Inceptive Cellular Population: The Relationship between Stem Cells and Aging
  • 本地全文:下载
  • 作者:Catherine E. Symonds ; Umberto Galderisi ; Antonio Giordano
  • 期刊名称:Aging
  • 出版年度:2009
  • 卷号:01
  • 期号:04
  • 出版社:U.S.Department of Health & Human Service
  • 摘要:The average life expectancy worldwide has about doubled and the global population has increased six fold over the past century. With improving health care in the developed world there is a proportional augmentation in the treatment necessary for elderly patients occasioning the call for increased research in the area of aging and age-related diseases. The manifestation of this research has been focalized on the causative cellular processes and molecular mechanisms involved. Here we will discuss the efforts of this research in the area of stem cells, delving into the regulatory mechanisms and how their de-regulation could be attributed to aging and age-related diseases.
  • 关键词:stem cells; senescence; cell cycle; apoptosis; aging; differentiation
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