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  • 标题:Growth and Aging: A Common Molecular Mechanism
  • 本地全文:下载
  • 作者:Mikhail V. Blagosklonny ; Michael N. Hall
  • 期刊名称:Aging
  • 出版年度:2009
  • 卷号:01
  • 期号:04
  • 出版社:U.S.Department of Health & Human Service
  • 摘要:It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.
  • 关键词:Aging; growth; rapamycin; TOR; mitochondria
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