摘要：Dietary restriction (DR) has been shown to robustly modulate organismal lifespan in multiple species. The powerful genetic tools in yeast, worms and flies hold great promise in unraveling the secrets of the molecular mechanisms of this process that have been elusive for more than seven decades, since DR was first described to extend lifespan in mice. In a recent study, Carrano and colleagues report the discovery that an E2/E3 ubiquitin ligase set are required for the lifespan extending effects of DR in C.elegans [1].
