文章基本信息
- 标题：Microwave-assisted Efficient Synthesis of Isatins and spiro -Thiadiazolines under Green Chemistry Protocol
- 本地全文：下载
- 作者：M. M. Hossain ; M. A. Foysal ; M. Mahabub 等
- 期刊名称：Journal of Scientific Research
- 印刷版ISSN：2070-0237
- 电子版ISSN：2070-0245
- 出版年度：2010
- 卷号：2
- 期号：02
- 页码：322-329
- DOI：10.3329/jsr.v2i2.3731
- 出版社：Rajshahi University
- 摘要：
MW-assisted treatment of oximinoacetanilides obtained from substituted primary aromatic amines was carried out in conc. H2SO4 medium for 5-10 sec to give cyclic amides (isatins) through intramolecular cyclization by means of electrophilic aromatic substitution. Isatins reacted with thiosemicarbazide under MW-condition gave the corresponding Schiff-bases. The Schiff-bases undergo cyclization in presence of minimal Ac2O under MW-irradiation for 3-4 min to give the spiro -thiadiazoline acetyl derivatives in excellent yield.
Keywords : Microwave-synthesis; Isatins; Schiff-base; spiro -Thiadiazoline; Green chemistry.
© 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.
DOI: 10.3329/jsr.v2i2.3731 J. Sci. Res. 2 (2), 322-329 (2010)
- 关键词：Green chemistry.
