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  • 标题:Laevifonol: A Unique Dimer Oligostilbene from the Stem Bark of Vatica Odorata
  • 本地全文:下载
  • 作者:Wan Zuraida Wan Mohd Zain ; Kamaruzaman Jusoff
  • 期刊名称:World Applied Sciences Journal
  • 印刷版ISSN:1818-4952
  • 电子版ISSN:1991-6426
  • 出版年度:2010
  • 卷号:8
  • 期号:09
  • 出版社:International Digital Organization for Scientific Information Publications
  • 摘要:

    The isolation of laevifonol (dimerstilbene) in Vatica odorata is the second time for its present in
    Vatica sp. This compound is a unique oligostilbene formed from a condensation between g-viniferin and
    ascorbic acid and was firstly isolated from Shorea laevifonia and recently from Vatica umbonata. The structure
    of laevifonol was established on the basis of their spectral data, including UV, IR and NMR spectra and also
    in comparison with the previously reported data. Cytotoxic properties was evaluated against murine
    leukimia P-388 cells and Artemia salina which resulting not strongly inhibited with IC values of 60.5 ìM and 50
    > 796.2 ìM, respectively. Antibacterial activity also was screened against two gram positive bacteria (Bacillus
    subtilis and Staphylococcus aeureus) and one gram negative bacteria (Escherichia coli). The antibacterial
    testing was carried out by using the disc diffusion method. Blanc disc of 6mm diameter was loaded with 1000
    ìg/ml of the compound applied to the inoculate plate. The compound showed moderate activity against all the
    bacteria with inhibition zones of 0.5 mm against E.coli and B.subtilis and 0.1 mm against S. aerues compared
    to positive control (Erythromycin 60 ìg) with 0.13 mm, 0.03 mm and 0.1 mm each. The present investigation is
    apart of our ongoing studies on the oligostilbene of Malaysian Dipterocarpacaeae in which no phytochemical
    data was recorded on V. odorata.

  • 关键词:Oligostilbene ; Dipterocarpaceae ; Vatica odorata ; Laevifonol ; Biological activity
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