The isolation of laevifonol (dimerstilbene) in Vatica odorata is the second time for its present in
Vatica sp. This compound is a unique oligostilbene formed from a condensation between g-viniferin and
ascorbic acid and was firstly isolated from Shorea laevifonia and recently from Vatica umbonata. The structure
of laevifonol was established on the basis of their spectral data, including UV, IR and NMR spectra and also
in comparison with the previously reported data. Cytotoxic properties was evaluated against murine
leukimia P-388 cells and Artemia salina which resulting not strongly inhibited with IC values of 60.5 ìM and 50
> 796.2 ìM, respectively. Antibacterial activity also was screened against two gram positive bacteria (Bacillus
subtilis and Staphylococcus aeureus) and one gram negative bacteria (Escherichia coli). The antibacterial
testing was carried out by using the disc diffusion method. Blanc disc of 6mm diameter was loaded with 1000
ìg/ml of the compound applied to the inoculate plate. The compound showed moderate activity against all the
bacteria with inhibition zones of 0.5 mm against E.coli and B.subtilis and 0.1 mm against S. aerues compared
to positive control (Erythromycin 60 ìg) with 0.13 mm, 0.03 mm and 0.1 mm each. The present investigation is
apart of our ongoing studies on the oligostilbene of Malaysian Dipterocarpacaeae in which no phytochemical
data was recorded on V. odorata.