摘要：Summary (Isoprostanes and oxidative stress in brain damage of the newborn). - Isoprostanes are a family of
biologically active molecules recently characterized, which is emerging as a new class of specific and reliable
markers of in vivo and ex vivo lipid peroxidation and oxidative damage. These molecules are stable, relatively
abundant and easily detectable by sensitive and specific analytical methods. In the last years, the measurement
of their levels in tissue homogenates or biological fluids has significantly improved our knowledge on the
involvement of oxidative stress in several neurological diseases. Here we present evidence indicating that
isoprostanes can be successfully used also to study the mechanisms involved in free radical brain damage following
hypoxic-ischaemic or inflammatory conditions in newborns and preterm infants.
