In this paper, a detailed comparison between different multiuser detectors for synchronous code-division multiple-access (CDMA) systems has been analyzed. Here speech signal is being converted into vectors in the form of matrix. Each vector in the matrix indicates the samples obtained from the speech signal. An algorithm has been described as measurement vector orthogonality and imposes an inner product constraint. Unlike the linear minimum mean-squared error (LMMSE) receiver, other multiuser detectors depends only on the signature vectors and does not require knowledge of the received amplitudes or the channel signal-to-noise ratio (SNR). The implementation can be done for linear and non linear detectors. The simulation results provided suggest that in certain cases the Maximum likelihood sequence estimator performs better with lower bit error rate when compared to linear equalizer and Decision feedback equalizer