BACKGROUND: This pilot study describes an Objective Structured Clinical Examination (OSCE) developed using Human Patient Simulation (HPS). METHODS: Eight residents completed two iterations of this HPS OSCE containing seven stations and utilizing checklists, global ratings, and scoring sheets. RESULTS: The first- and second-year residents scored similarly with mean scores of 64/104 and 62/123, respectively. No statistical difference was noted between the resident scores. CONCLUSIONS: The HPS OSCE is feasible for small groups. A larger study will be needed to determine the effectiveness of this tool for evaluation.