Health education is a behavioral science, with teaching and learning activities focused on both behavioral objectives and learning objectives. With health behavior change and adoption of healthy lifestyle choices as its goal, health education relies heavily on social support systems and environmental factors to facilitate this objective. Providing effective online health education focused on behavior change can be a challenge. Students may feel isolated and are unable to draw on the strength and encouragement that can be found in a traditional learning environment. Web 2.0 applications such as Facebook offer ways for students to both provide and gain the social support necessary to make behavior change a reality. This instructional design note offers detailed direction for creating, implementing, and assessing the use of Facebook in an online health education course to facilitate individual health behavioral change.