Abstract: Toxicity of dermally absorbed dichlorvos was studied in rats, based on its
effects on internal organs, and on phagocytic and bactericidal activity of the neutrophile
system. The studies were conducted on 30 female rats of Wistar strain. The animals
were divided into three groups, two of which were experimentally exposed to dermal
absorption of dichlorvos (37.5 mg/kg - 1/2 LD50 or 7.5 mg/kg - 1/10 LD50), and one
control group which was exposed to dermal absorption of the solvent. The animals were
exposed to dermal absorption for 4 hours daily for a period of 4 weeks. After 28 days,
the rats were anaesthetized, blood was drawn from the heart to evaluate the activity of
the neutrophilic system, and the internal organs excised for histological and ultrastructural
studies. Dermally absorbed dichlorvos caused histopathological changes in lungs,
lymphatic glands and thymus, as well as histopathological and ultrastructural changes in
liver, kidneys and heart muscle. Dichlorvos stimulated the bactericidal and phagocytic
activity of neutrophils