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文章基本信息

  • 标题:Autoimmunity in Hepatitis C Virus Infection
  • 作者:MJ Dhorda ; SR Kankonkar ; AL Kirpalani
  • 期刊名称:Bombay Hospital Journal
  • 印刷版ISSN:0524-0182
  • 出版年度:2000
  • 卷号:42
  • 期号:02
  • 出版社:Bombay Hospital Institute of Medical Sciences
  • 摘要:

    Hepatitis 'C' virus (HCV) is a positive strand RNA virus[1] classified as a separate genus within the family Flaviviridae, though this classification may be changed.[2] Its genome consists of about 9400 bases that code for a polyprotein of approximately 3000 amino acids.1 This polyprotein is cleaved after translation by cellular or viral proteases to give the structural proteins that have a presumed enzymatic role in viral replication.[3] HCV is known to have 11 distinct genotypes, with over seventy subtypes, each associated with a varying degree of severity of disease, prognosis and response to interferon therapy.[4]

  • 关键词:Hepatitis C Virus Infection;Autoimmunity;Viral Proteases;Structural Proteins;Disease Prognosis
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