Out of 3279 blood cultures processed in the Microbiology department, over a period of 1 1/2 years, 109 strains of Salmonella typhi (S. typhi) were isolated out of 558 positive blood cultures. Processing of the blood cultures was done by a Semi-automated machine, BACTEC 9050. 60.8 per cent strains were multi drug resistant and ampicillin, chloramphenicol, co-trimoxazole and tetracycline (ACCoT) was the commonest pattern of drug resistance. 66 per cent strains were resistant to nalidixic acid (NA), the first member of quinolone class of antimicrobial agents. Though none of the S. typhi strains showed resistance to ciprofloxacin, when tested by Kirby-Bauer disc diffusion method, it was observed that S. typhi resistant to NA showed increased Minimum Inhibiting Concentration (MIC) for ciprofloxacin.