Multiple primary presentation of squamous cell carcinoma is a rare clinical entity. We report a case that was treated for perianal squamous cell carcinoma 10 years ago and currently presenting with squamous cell carcinoma at two diverse sites (lung and palm). The underlying aetiology was palmoplantar hyperkeratosis.
A medline search of the literature revealed 12 cases of palmoplantar hyperkeratosis associated with bronchial carcinoma. However, this case may be the first report of a triple primary cancer in the literature