The current literature states that the development in Down Syndrome occurs with delay when compared with that of children with typical neuropsychomotor development. But, studies have shown that stimulation is important in the process of development of this specific population by providing more opportunities for experience, possibly minimizing the large deficits associated with it. The present research aims to evaluate the perceptual, motor and cognitive development of children with Down Syndrome, investigating the possible interdependence between the motricity and the intelligence structuring. This research involved 10 children with Down Syndrome aged between one and five years. For data collection a structured observation of motor behavior to describe the patterns of locomotion, manipulation, stability, and perception was used, besides the adapted piagetian Clinical Method for observation and description of the construction of the concepts of permanent object, physical causality, space and time concerning the sensory-motor stage of cognitive development. The items related to both evaluations were categorized in a qualitative way from pre-established criteria. The data were processed using an exploratory and descriptive statistical analysis. It was observed that the major motor deficits and higher cognitive gaps were presented by the younger children in the sample. In the same way, the greatest interdependence in the relation among the different evaluated items occurred in these same children. It is believed that, with the passing of years, the development process of these children tends to get closer to what is typically expected, confirming the importance of long-term stimulation for children with Down Syndrome.