文章基本信息
- 标题：Levels of awakening salivary CgA in response to stress in healthy subjects
- 本地全文：下载
- 作者：Rei Den ; Masahiro Toda ; Masako Ohira 等
- 期刊名称：Environmental Health and Preventive Medicine
- 印刷版ISSN：1342-078X
- 电子版ISSN：1347-4715
- 出版年度：2011
- 卷号：16
- 期号：3
- 页码：155-157
- DOI：10.1007/s12199-010-0179-5
- 语种：English
- 出版社：Springer Japan
- 摘要：Objects
To determine the changes in salivary chromogranin A (CgA) levels upon awakening in response to of stress by investigating the relationship between salivary CgA levels and the stress response as assessed by GHQ-28 tests.
MethodsThe study cohort comprised 40 healthy male university students (age range 19–22 years). Salivary CgA levels were measured at 7:00 a.m. (awakening) and at 7:30, 8:00, and 8:30 a.m. (after awakening).
ResultsThe salivary CgA level was 0.91 ± 0.20 and 0.42 ± 0.1 pmol/ml at 7:00 a.m. in students scoring low ( n = 26) and high ( n = 14), respectively, on the “severe depression” subscale. This difference in salivary CgA levels at 7:00 between high and low scorers was statistically significant ( p Conclusions
Our findings indicate that depression may influence secretions of salivary CgA via chronic stress-related attenuation of the sympathetic–adrenomedullary system activity.
- 关键词：Chromogranin A ;Stress ;Awakening ;Saliva ;Depression
