This study seeks to ascertain and document the extent to which investment in IT by banks in Ghana can impact on their profitability using the Balanced Scorecard (BSC) framework. The study uses the extensive panel dataset of 15 banks sampled from the Ghanaian banking industry over a 10-year period (1998-2007. The study finds that banks which maintain high levels of investments in IT increased return on assets (ROA) and return on equity (ROE).