This study investigates the key factors affecting success of women entrepreneurs in Southern region in Malaysia. Data was collected using a self administered questionnaire that was distributed through mail survey. Multiple regression analysis was used as a more suitable methodology to identify the important determinants of success of women entrepreneurs. The results suggest that family support, social ties and internal motivation affect positively and significantly to the success of women entrepreneurs in the small business. The survey result also shows that women entrepreneurs having problem when they enter into the business. The implications of this study are discussed along with some recommendations.