The study aims to examine the relationship between self-esteem and perceived social support among the Malaysian adolescents. Gender differences of perceived social support and self-esteem among the respondents were also investigated. To achieve the objectives of the study, a survey was conducted with a relatively large (n=460) random samples of adolescents, aged 16-20, drawn from schools, colleges and universities in Malaysia. The Self-esteem Rating Scale (SERS) and the Multidimensional Scale of Perceived Social Support (MSPSS) were used in the study. The results indicated that there were no gender differences in perceived social support and self-esteem among adolescents. However, a positive correlation was found between perceived social support and self-esteem. The study also found peer support was the highest form of perceived social support.