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  • 标题:A proof of the DBRF-MEGN method, an algorithm for deducing minimum equivalent gene networks
  • 本地全文:下载
  • 作者:Koji Kyoda ; Kotaro Baba ; Hiroaki Kitano
  • 期刊名称:Source Code for Biology and Medicine
  • 印刷版ISSN:1751-0473
  • 电子版ISSN:1751-0473
  • 出版年度:2011
  • 卷号:6
  • 期号:1
  • 页码:12
  • DOI:10.1186/1751-0473-6-12
  • 语种:English
  • 出版社:BioMed Central
  • 摘要:We previously developed the DBRF-MEGN (d ifference-b ased r egulation f inding-m inimum e quivalent g ene n etwork) method, which deduces the most parsimonious signed directed graphs (SDGs) consistent with expression profiles of single-gene deletion mutants. However, until the present study, we have not presented the details of the method's algorithm or a proof of the algorithm. We describe in detail the algorithm of the DBRF-MEGN method and prove that the algorithm deduces all of the exact solutions of the most parsimonious SDGs consistent with expression profiles of gene deletion mutants. The DBRF-MEGN method provides all of the exact solutions of the most parsimonious SDGs consistent with expression profiles of gene deletion mutants.
  • 关键词:DBRF-MEGN method ; proof ; algorithm ; gene network ; expression profiles
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