This article aims to reflect on the initial mother-child relationship and the psychological aspects of psychosomatic diseases, particularly psoriasis (chronic skin disease). It is a theoretical and clinical qualitative study, based on qualitative analysis of the contents of clinical material obtained in psychotherapy of two children with psoriasis treated in a public hospital. The comprehension of the material reported is based in psychodynamic orientation authors, who seek to understand the meanings of the skin to the human psyche as an organ, that sets the concrete and psychic limit of Me and Not-me. The literature indicates which difficulties in the mother-child relationship might be manifested through disorders in this organ. It is considered through this research that the play therapy helped the children to understand and deal with aggression, with anguish and suffering associated with psoriasis.