期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：4
页码：1075-1080
DOI：10.1073/pnas.0305803101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Amyloid-{beta} peptide (A{beta}) is central to the pathogenesis of Alzheimer's disease, and the low-density lipoprotein receptor-related protein (LRP) has been shown to alter A{beta} metabolism in vitro. Here, we show that overexpression of a functional LRP minireceptor in the brain of PDAPP mice results in age-dependent increase of soluble brain A{beta
