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  • 标题:β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
  • 本地全文:下载
  • 作者:D. Scott Witherow ; Tiffany Runyan Garrison ; William E. Miller
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2004
  • 卷号:101
  • 期号:23
  • 页码:8603-8607
  • DOI:10.1073/pnas.0402851101
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:In addition to their roles in desensitization and signaling of seven-membrane-spanning receptors, {beta}-arrestins have been more recently implicated in regulating non-seven-membrane-spanning receptor pathways. By using a yeast two-hybrid screen, we identified the inhibitor of NF-{kappa}B, I{kappa}B{alpha
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