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  • 标题:Requirement of c-myb in T cell development and in mature T cell function
  • 本地全文:下载
  • 作者:Yen K. Lieu ; Atul Kumar ; Anthony G. Pajerowski
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2004
  • 卷号:101
  • 期号:41
  • 页码:14853-14858
  • DOI:10.1073/pnas.0405338101
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Previous reports have suggested that the protooncogene c-myb participates in T cell development in the thymus and mature T cell proliferation. We have generated two T cell-specific c-myb knockout mouse models, myb/LckCre and myb/CD4Cre. We have demonstrated that c-myb is required for the development of thymocytes at the DN3 stage, for survival and proliferation of double-positive thymocytes, for differentiation of single-positive CD4 and CD8 T cells, and for the proliferative responses of mature T cells. In addition, our data show that c-myb is directly involved in the formation of double-positive CD4+CD8+CD25+, CD4+CD25+, and CD8+CD25+ T cells, developmental processes that may imply a role for c-myb in autoimmune dysfunction.
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