期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：44
页码：15766-15771
DOI：10.1073/pnas.0402824101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The vestibular semicircular canals respond to angular acceleration that is integrated to angular velocity by the biofluid mechanics of the canals and is the primary origin of afferent responses encoding velocity. Surprisingly, some afferents actually report angular acceleration. Our data indicate that hair-cell/afferent synapses introduce a mathematical derivative in these afferents that partially cancels the biomechanical integration and results in discharge rates encoding angular acceleration. We examined the role of convergent synaptic inputs from hair cells to this mathematical differentiation. A significant reduction in the order of the differentiation was observed for low-frequency stimuli after {gamma}-aminobutyric acid type B receptor antagonist administration. Results demonstrate that {gamma}-aminobutyric acid participates in shaping the temporal dynamics of afferent responses.
