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  • 标题:Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro
  • 本地全文:下载
  • 作者:Peter Mellroth ; Jenny Karlsson ; Janet Håkansson
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2005
  • 卷号:102
  • 期号:18
  • 页码:6455-6460
  • DOI:10.1073/pnas.0407559102
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Drosophila knockout mutants have placed peptidoglycan recognition proteins (PGRPs) in the two major pathways controlling immune gene expression. We now examine PGRP affinities for peptidoglycan. PGRP-SA and PGRP-LCx are bona fide pattern recognition receptors, and PGRP-SA, the peptidoglycan receptor of the Toll/Dif pathway, has selective affinity for different peptidoglycans. PGRP-LCx, the default peptidoglycan receptor of the Imd/Relish pathway, has strong affinity for all polymeric peptidoglycans tested and for monomeric peptidoglycan. PGRP-LCa does not have affinity for polymeric or monomeric peptidoglycan. Instead, PGRP-LCa can form heterodimers with LCx when the latter is bound to monomeric peptidoglycan. Hence, PGRP-LCa can be said to function as an adaptor, thus adding a new function to a member of the PGRP family.
  • 关键词:Imd/Relish ; innate immunity ; pattern recognition ; Toll/Dif
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