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  • 标题:Neuronal modulation of calcium channel activity in cultured rat astrocytes.
  • 本地全文:下载
  • 作者:V Corvalan ; R Cole ; J de Vellis
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1990
  • 卷号:87
  • 期号:11
  • 页码:4345-4348
  • DOI:10.1073/pnas.87.11.4345
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The patch-clamp technique was used to study whether cocultivation of neurons and astrocytes modulates the expression of calcium channel activity in astrocytes. Whole-cell patch-clamp recordings from rat brain astrocytes cocultured with rat embryonic neurons revealed two types of voltage-dependent inward currents carried by Ca2+ and blocked by either Cd2+ or Co2+ that otherwise were not detected in purified astrocytes. This expression of calcium channel activity in astrocytes was neuron dependent and was not observed when astrocytes were cocultured with purified oligodendrocytes.
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