首页    期刊浏览 2024年11月26日 星期二
登录注册

文章基本信息

  • 标题:Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.
  • 本地全文:下载
  • 作者:L E Samelson ; A F Phillips ; E T Luong
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1990
  • 卷号:87
  • 期号:11
  • 页码:4358-4362
  • DOI:10.1073/pnas.87.11.4358
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Activation of the T-cell antigen receptor (TCR) results in tyrosine phosphorylation of the TCR zeta chain and other intracellular substrates. Two other T-cell integral membrane proteins, CD4 and CD8, are associated with the protein-tyrosine kinase (PTK), lck. Despite evidence that activation of this enzyme results in TCR-zeta chain phosphorylation, it has not been shown that the TCR activates lck. We have sought evidence that the TCR is associated with a PTK. In this study we use digitonin to solubilize a murine T-cell hybridoma and demonstrate that antibodies binding extracellular but not intracellular domains of the TCR specifically coprecipitate only the fyn PTK and not lck or yes, two other kinases found in these cells. The association of the fyn PTK with the TCR might enable the T cell to independently regulate two PTKs through surface receptors.
国家哲学社会科学文献中心版权所有