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  • 标题:Changed distribution of sodium channels along demyelinated axons
  • 本地全文:下载
  • 作者:J D England ; F Gamboni ; S R Levinson
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1990
  • 卷号:87
  • 期号:17
  • 页码:6777-6780
  • DOI:10.1073/pnas.87.17.6777
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Voltage-gated sodium channels are largely localized to the nodes of Ranvier in myelinated axons, providing a physiological basis for saltatory conduction. What happens to these channels in demyelinated axons is not known with certainty. Experimentally demyelinated axons were examined by using a well-characterized, polyclonal antibody directed against sodium channels. Immunocytochemical and radioimmunoassay data were consistent with the distribution of an increased number of sodium channels along segments of previously internodal axon. These findings affirm the plasticity of sodium channels in demyelinated axolemma and may be relevant to understanding how axons recover conduction after demyelination.
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