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  • 标题:Chemical carcinogenesis: too many rodent carcinogens.
  • 本地全文:下载
  • 作者:B N Ames ; L S Gold
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1990
  • 卷号:87
  • 期号:19
  • 页码:7772-7776
  • DOI:10.1073/pnas.87.19.7772
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis and thus carcinogenesis. The animal data are consistent with this mechanism, because a high proportion--about half--of all chemicals tested (whether natural or synthetic) are indeed rodent carcinogens. We conclude that at the low doses of most human exposures, where cell killing does not occur, the hazards to humans of rodent carcinogens may be much lower than is commonly assumed.
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