首页    期刊浏览 2024年11月28日 星期四
登录注册

文章基本信息

  • 标题:Isolation of cDNA encoding a newly identified major allergenic protein of rye-grass pollen: intracellular targeting to the amyloplast.
  • 本地全文:下载
  • 作者:M B Singh ; T Hough ; P Theerakulpisut
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1991
  • 卷号:88
  • 期号:4
  • 页码:1384-1388
  • DOI:10.1073/pnas.88.4.1384
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:We have identified a major allergenic protein from rye-grass pollen, tentatively designated Lol pIb of 31kDa and with pI 9.0. A cDNA clone encoding Lol pIb has been isolated, sequenced, and characterized. Lol pIb is located mainly in the starch granules. This is a distinct allergen from Lol pI, which is located in the cytosol. Lol pIb is synthesized in pollen as a pre-allergen with a transit peptide targeting the allergen to amyloplasts. Epitope mapping of the fusion protein localized the IgE binding determinant in the C-terminal domain.
国家哲学社会科学文献中心版权所有