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  • 标题:The c-mos gene product is required for cyclin B accumulation during meiosis of mouse eggs
  • 本地全文:下载
  • 作者:S J O'Keefe ; A A Kiessling ; G M Cooper
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1991
  • 卷号:88
  • 期号:17
  • 页码:7869-7872
  • DOI:10.1073/pnas.88.17.7869
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The c-mos protooncogene is expressed as a maternal message that is required for oocyte meiosis. The mechanism of action of c-mos was investigated by analysis of mouse eggs injected with antisense c-mos oligonucleotides. In antisense-injected eggs, maturation-promoting factor was not reactivated after the completion of meiosis I, leading to the formation of nuclei containing decondensed chromatin within 2-3 hr after polar body extrusion. This was correlated with a failure of the injected eggs to accumulate newly synthesized cyclin B. The c-mos protooncogene thus appears to affect the pathway that regulates cyclin B stability during meiosis of mouse eggs.
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