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  • 标题:Hidden Markov models of biological primary sequence information.
  • 本地全文:下载
  • 作者:P Baldi ; Y Chauvin ; T Hunkapiller
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1994
  • 卷号:91
  • 期号:3
  • 页码:1059-1063
  • DOI:10.1073/pnas.91.3.1059
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Hidden Markov model (HMM) techniques are used to model families of biological sequences. A smooth and convergent algorithm is introduced to iteratively adapt the transition and emission parameters of the models from the examples in a given family. The HMM approach is applied to three protein families: globins, immunoglobulins, and kinases. In all cases, the models derived capture the important statistical characteristics of the family and can be used for a number of tasks, including multiple alignments, motif detection, and classification. For K sequences of average length N, this approach yields an effective multiple-alignment algorithm which requires O(KN2) operations, linear in the number of sequences.
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