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  • 标题:A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family.
  • 本地全文:下载
  • 作者:M van Zeijl ; S V Johann ; E Closs
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1994
  • 卷号:91
  • 期号:3
  • 页码:1168-1172
  • DOI:10.1073/pnas.91.3.1168
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Retrovirus infection is initiated by binding of the viral envelope glycoprotein to a cell-surface receptor. The envelope proteins of type C retroviruses of mammals demonstrate similarities in structural organization and protein sequence. These similarities suggest the possibility that retroviruses from different interference groups might use related proteins as receptors, despite the absence of any relationship between retrovirus receptors isolated to date. To investigate this possibility, we have identified a human cDNA clone encoding a protein closely related to the receptor for gibbon ape leukemia virus and have found that it functions as the receptor for the amphotropic group of murine retroviruses. Expression of this protein (GLVR-2) is likely to be a requirement for infection of human cells by amphotropic retroviral vectors for purposes of gene therapy.
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