期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1982
卷号：79
期号：2
页码：395-399
DOI：10.1073/pnas.79.2.395
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A general theory for the initial phase of T cell independent immune response is derived from elementary physical-chemical considerations and from the premise that response entails a quantized linkage of cell surface receptors. The theory leads to the construction of explicit antigen dose--response and antigen dose--suppression curves, to the calculation of intrinsic affinities for receptors, and to the deduction that receptors are divalent in character. The theory may be applicable to other cell surface phenomena wherein requirements for stimulation and suppression are equivalent to those found in the immune system.
